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           APIs&Intermediates Chemicals of Shanghai APIs Chemical Co., Ltd  

           

Product Indentification
 

Name:    Dapagliflozin
Synonyms:    BMS-512148
CAS Registry Number:   461432-26-8
Molecular Formula:   C21H25ClO6
Molecular Weight:    408.87
Molecular Structure:  

 

 

                     In stock!   Click for COA   50g in stock!

 

                     

                    Appearance: white solid                 

 

 

                    Purity: 99%min

 

                      

                    For Research Use Only

 

 

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Related drugs for SGLT Target:

 

[ Pfizer; Lexicon(LX-4211); Roche(CSG-452, R-7201);Taisho(TS-071)]  >> Phase II

               

[BMS(Dapagliflozin); Mitsubishi Tanabe(Canagliflozin); Astellas(ASP-1941) ;Boehringer Ingelheim(BI-44847)]  >> Phase III

 

 

Related intermediates:

 

          (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone(461432-22-4)

 

          5-bromo-2-chloro-4-ethoxydiphenylmethane(461432-23-5)

 

 

Related pages:


     Search Dapagliflozin or BMS-512148 in google
     Search CAS 461432-26-8  in google
     Search C21H25ClO6 in google

 

Related info:

 

       Dapagliflozin inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine. The efficacy of the this medication class has yet to be determined, but in initial clinical trials, dapagliflozin lowers HbA1c by 0.90 percentage points when added to metformin.

 

 

 

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