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Product Indentification

Name:   ABT888
Synonyms:   Veliparib
CAS Registry Number:   912444-00-9 or 912445-05-7
Molecular Formula:   C13H16N4O
Molecular Weight:    244.29
Molecular Structure:  



                    In stock!Bulk!          


                   Appearance:  white solid






                   ee:99% min



                   For Research Used Only



                   Inquiry (H1NMR,HPLC,LC-MS)



                   The process of ABT888(CAS#912444-00-9)



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Related pages:

     Search ABT888 in google
     Search CAS 912444-00-9  or 912445-05-7  in google
     Search C13H16N4O in google


Related info:


        ABT-888 is a potent inhibitor of both PARP-1 and PARP-2 with Kis of 5.2and 2.9 nmol/L, respectively. The comp-ound has good oral bioavailability and crosses the blood-brain barrier. ABT-888 strongly potentiated temozolomide in the B16F10 s.c. murine melanoma model. PARP inhibition dramatically increased the efficacy of temozolomide at ABT-888 doses as low as 3.1mg/kg/d and a maximal efficacy achieved at 25 mg/kg/d. In the 9L orthotopic rat gliomamodel, temozolomide alone exhibited minimal efficacy, whereas ABT-888, when combined with temozolomide, significantly slowed tumor progression. In the MX-1 breast xenograft model(BRCA1 deletion and BRCA2 mutation), ABT-888 potentiated cisplatin, carboplatin, and cyclophosphamide, causing regression of established tumors, whereas with comparable doses of cytotoxic agents alone, only modest tumor inhibition was exhibited. Finally, ABT-888 potentiated radiation (2 Gy/d 10) in an HCT-116 colon carcinoma model. In each model, ABT-888 did not display single-agentactivity.





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