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Product Indentification

Name:    MDV3100
Synonyms:    4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methylbenzamide
CAS Registry Number:   915087-33-1
Molecular Formula:   C21H16F4N4O2S
Molecular Weight:    464.44
Molecular Structure:  

3D structure




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Related pages:

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     Search CAS 915087-33-1    in google
     Search C21H16F4N4O2S in google


Biological Activity:

     MDV3100 is an androgen-receptor (AR) antagonist with IC50 of 36 nM. MDV3100 is an experimental androgen receptor antagonist drug developed by the pharmaceutical company Medivation for the treatment of castration-resistant prostate cancer currently in Phase 3 clinical trials.[Results so far have been encouraging; Medivation has reported up to an 89% decrease in prostate specific antigen serum levels after a month of taking the medicine.Early preclinical studies also suggest that MDV3100 inhibits breast cancer cell growth.




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