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Product Indentification


Name:   BTZ043
Synonyms:   BZT043; 2-[2-S-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one


CAS Registry Number:   1161233-85-7
Molecular Formula:   C17H16F3N3O5S
Molecular Weight:    431.39
Molecular Structure:    







                    Storage: 4 deg.                 



                    For Research Use Only



                    Inquiry (H1NMR,HPLC,LC-MS)



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Biological Activity of BTZ043:

BTZ043 mainly targets the enzyme decaprenylphosphoryl-b-D-ribose 2-epimerase. Inhibition of this enzymatic activity abolishes the formation of decaprenylphosphoryl arabinose, a key precursor that is required for the synthesis of the cell-wall arabinans, thus provoking cell lysis and bacterial death. [1]
BTZ043 displayed similar activity against all clinical isolates of M. tuberculosis that were tested, including multidrug-resistant and extensively drug-resistant strains. The MIC of BTZ043 against M. tuberculosis H37Rv and Mycobacterium smegmatis were 1 ng/ml (2.3 nM) and 4 ng/ml (9.2 nM), respectively, which compares favorably with those of the existing TB drugs isoniazid (INH) (0.02 to 0.2 mg/ml) and ethambutol (EMB) (1 to 5 mg/ml). [1]

References on BTZ043:
[1] Vadim Makarov et al. Science. 2009 May 8;324(5928):801-4









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