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           APIs&Intermediates Chemicals of Shanghai APIs Chemical Co., Ltd 

           

             

 

Product Indentification
 

 

Name:   Banoxantrone dihydrochloride
Synonyms:   1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride
CAS Registry Number:   136470-65-0
Molecular Formula:   C22H28N4O6.2HCl
Molecular Weight:    517.4
Molecular Structure:    

 

 

 

                    Purity:99%min

 

 

                    Storage: 4 deg.                 

 

 

                    For Research Use Only

 

 

                    Inquiry (H1NMR,HPLC,LC-MS)

 

 

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Biological Activity


Bioreductive prodrug; activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Displays little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100 νM). Exhibits anti-tumor efficacy in vivo when combined with oxic cell cytotoxins; enhances the anti-tumor effect of cyclophosphamide (Cat. No. 4091) in a mouse tumor model.

 

 

 

 

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