Chemicals of Shanghai APIs Chemical Co.,
BN 83495；STX 64；667
|CAS Registry Number:
Storage: 4 deg.
For Research Use Only
Appearance: white powder
Store at 4˚C
STX64 is a potent, irreversible inhibitor of
steroid sulfatase. Inhibition of steroid
sulfatase (STS), the enzyme responsible for the
hydrolysis of steroid sulfates, represents a
potential novel treatment for postmenopausal
women with hormone-dependent breast cancer.
Estrone and DHEA are formed by this sulfatase
pathway and can be converted to steroids (estradiol
and androstenediol, respectively), which have
potent estrogenic properties. STX64 (667 coumate)
is a potent tricylic coumarin-based sulfamate
that irreversibly inhibits STS activity (IC50
= 8 nM in a placental microsomal assay system).
Estrone sulfamate (EMATE) is also a potent STS
inhibitor, but has estrogenic activity.