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Product Indentification


Name:   BN-83495
Synonyms:   6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate

BN 83495;STX 64;667 COUMATE

CAS Registry Number:   288628-05-7
Molecular Formula:   C14H15NO5S
Molecular Weight:    309.07
Molecular Structure:    






                    Storage: 4 deg.                 



                    For Research Use Only



                    Inquiry (H1NMR,HPLC,LC-MS)



Related pages:


     Search BN-83495 in google
     Search CAS 288628-05-7  in google
     Search C14H15NO5S  in google




                   Appearance: white powder

                   Store at 4˚C




STX64 is a potent, irreversible inhibitor of steroid sulfatase. Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. STX64 (667 coumate) is a potent tricylic coumarin-based sulfamate that irreversibly inhibits STS activity (IC50 = 8 nM in a placental microsomal assay system). Estrone sulfamate (EMATE) is also a potent STS inhibitor, but has estrogenic activity.









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