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           APIs&Intermediates Chemicals of Shanghai APIs Chemical Co., Ltd 

           

Product Indentification
 

 

Name:   Ponatinib
Synonyms:   AP24534
CAS Registry Number:   943319-70-8
Molecular Formula:   C29H27F3N6O
Molecular Weight:    532.56
Molecular Structure:    

 

                    In stock!

 

                    Purity:99%min

 

 

                    Storage: 4 deg.                 

 

 

                    For Research Use Only

 

 

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Biological Activity of Ponatinib (AP24534):


     Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor with IC50 of 0.37, 2, 1.5, 2.2, 1.1, 1and 0.24 nM for native pan-BCR-ABL, mutated form, VEGFR2, FGFR1, PDGFRα, mutant FLT3 phosphorylation and LYN.


 

 

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