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           APIs&Intermediates Chemicals of Shanghai APIs Chemical Co., Ltd 

        

Product Indentification
 

Name:   JNJ-26481585
Synonyms:   N-hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide
CAS Registry Number:   875320-29-9
Molecular Formula:   C21H26N6O2
Molecular Weight:    394.21
Molecular Structure:    

 

 

                    In stock!

 

                   Purity:99%min

 

 

                   Storage: -20C for 2 years

 

 

                   For Research Used Only

 

 

                   Inquiry (H1NMR,HPLC,LC-MS)

 

 

 

Related pages:


     Search JNJ-26481585 in google
     Search CAS 875320-29-9   in google
     Search C21H26N6O2 in google

 

 

Biological Activity:


       JNJ-26481585 is an orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation.

 

 

 

 

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