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Product Indentification

Name:   TW-37
Synonyms:   N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide

TW-37; Bcl-2 Inhibitor

CAS Registry Number:   877877-35-5
Molecular Formula:   C33H35NO6S
Molecular Weight:    573.70
Molecular Structure:    


                  In stock!




                   Storage: 4 deg C


                   For Research Use Only





Related Bcl-2 inhibitor:


                   ABT-737|852808-04-9                                                                                         ABT263|923564-51-6         


                   Gossypol|90141-22-3|12542-36-8|Gossypol-acetic acid                        Obatoclax mesilate|803712-79-0





Related pages:

     Search TW-37 in google
     Search CAS 877877-35-5   in google
     Search C33H35NO6S in google




Biological Activity

      Bcl-2 inhibitor (Ki values are 0.29 μM and 1.11 μM for Bcl-2 and Bcl-XL respectively). Inhibits the angiogenic potential of endothelial cells in vitro. Induces S-phase arrest and apoptosis in pancreatic cancer cell lines; also inhibits the activation of Notch-1 and Jagged-1 in vitro and in vivo.




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