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Product Indentification


Name:   ZSTK 474
Synonyms:   2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine
CAS Registry Number:   475110-96-4
Molecular Formula:   C19H21F2N7O2
Molecular Weight:    417.41
Molecular Structure:    


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                   Storage: 4 deg C



                  Inquiry (H1NMR,HPLC,LC-MS)



Biological Activity of ZSTK474


ZSTK474 is an inhibitor of PI3K γ (IC50 at 6 nM). This agent inhibits PI3K α and PI3K β with IC50 of 17 and 53 nM, respectively. ZSTK474 was identified from a chemical library of about 1500 triazine derivatives, and selected for their ability to block tumor cell growth. In preclinical studies ZSTK474 was orally administered to mice and displayed a strong anti-tumoral activity in xenograft models. Toxicity was reported to be moderate.



Related PI3K Inhibitors:



          GDC0941|957054-30-7                                                     ZSTK474|475110-96-4        


         NVP-BEZ 235|915019-65-7                                                               XL765|1123889-87-1


         AS-605240|648450-29-7                                                                    XL147|956958-53-5 


         S1462|1173900-33-8                                                                          TGX-221|663619-89-4


          CAL-101|870281-82-6                                                             TG100-115|677297-51-7


       GSK1059615|958852-01-1                                                              PKI-587|1197160-78-3


        GSK2126458|1086062-66-9                                                             PIK90|677338-12-4


       IC87114|371242-69-2                                                     PI-103|371935-74-9 






Related pages:

     Search ZSTK 474  in google
     Search CAS 475110-96-4    in google
     Search C19H21F2N7O2 in google




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