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Product Indentification


Name:    PHA 665752
Synonyms:   (2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine
CAS Registry Number:   477575-56-7
Molecular Formula:   C32H34Cl2N4O4S
Molecular Weight:    641.61
Molecular Structure:    



                   In stock!  Bulk!


                   Appearance:  yellow crystalline powder





                   Storage: 4 deg C



                  Inquiry (H1NMR,HPLC,LC-MS)



Biological Activity

Potent, selective and ATP-competitive inhibitor of MET kinase (IC50 values are 9, 68, 200, 1400, 3000, 3800 and 6000 nM for MET, Ron, Flk-1, c-abl, FGFR1, EGFR and c-src respectively and > 10000 nM for IGF-IR, PDGFR, AURORA2, PKA, PKBα, p38α, MK2 and MK3). Antitumor agent; inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts.



Related pages:

     Search PHA 665752  in google
     Search CAS 477575-56-7  in google
     Search C32H34Cl2N4O4S  in google





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